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Selective Redox Regulation of Cytokine Receptor Signaling by Extracellular Thioredoxin-1

A placebo-controlled study

The addition of erastin or high extracellular glutamate levels reduced cysteine, which inhibited system Xc(-) and led to GPx-4 inactivation and ferroptosis induction (13)

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( E ) Skov3 cells expressing the Her2 antigen were incubated with Herceptin together with gp34 1-179 , gp34 1-179W65F or ICOS-L 1-268

Lactoferrin is a multifunctional protein that modulates the function of immune cells and exerts hepatoprotective effects by regulating inflammatory responses