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Importantly, mitochondria play pivotal regulatory energetic roles that determine cell growth, metabolism, stress responses, and even cell death

[DOI] [PMC free article] [PubMed] [Google Scholar] 35.Gaugler J., James B., Johnson T., Reimer J., Solis M., Weuve J., Buckley R.F., Hohman T.J

Kahweol, derived from coffee, alleviated APAP-induced hepatocyte death, and its cell protection was related to the inhibition of ERS

Given its pivotal role in maintaining redox homeostasis, Nrf2 activation is an attractive therapeutic target for conditions characterized by oxidative stress 13 and can provide an environment for cellular repair and regeneration 14

doi: 10.1136/gut.27.11.1292 238 RoyJGalanoJDurandTGuennecJLLeeJC

PMID: 39485697, PMCID: PMC11563878, DOI: 10.1080/15389588.2024.2368595