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The liver was divided into portions: the first portion, from the largest hepatic lobule, was fixed in 10% formalin, while another portion, from a smaller lobule, was stored at 80C

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Then, the reaction mixtures were diluted with adequate amounts of 5 mM sodium phosphate buffer (pH 7.4) containing 10% (v/v) acetonitrile and filtered using a 0.45-m filter (Cosmonice filter W, Nacalai Tesque)

The efficacy of APAP is dose-dependent, which is affected by the PK in the different age groups

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Additionally, individual S