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Resistance to conventional tumor-targeting drugs such as cisplatin often creates metabolic vulnerabilities that are sensitive to treatment with metabolic inhibitors [15, 16]
10.1038/nrm3270 Nat
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French physician Michel Pistor developed the technique in 1952, and it has been refined over decades of clinical use in aesthetic medicine worldwide

Neuromelanin released from dying DA neurons in the SNpc activate microglia, increasing the sensitivity of DA neurons to oxidative stress-mediated cell death ( Dopamine neurons containing neuromelanin are especially more susceptible, indicating a possible role for neuromelanin in MPTP-toxicity ( Parkinsons disease-associated proteins like -syn, parkin, LRRK2, and DJ-1 have also been reported to activate microglia ( Conclusion The elements that potentially cause oxidative stress in PD are still unknown
