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Using structure-based analyses and cell models, including patient fibroblasts, of this variant, we found that the missense variant destabilized a critical loop, which disrupted the active site and caused a substantial loss of enzymatic function

doi: 10.1124/jpet.103.051300

At the same time, OS can promote the proliferation of theca-interstitial cells, upregulate CYP17, reduce serum SHBG levels, increase androgen secretion, improve the biological activity of serum free testosterone, and cause HA

Several recent studies also point to the importance of the ECM in facilitating metastatic tumour cell growth in the metastatic niche (BOX 3)

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Targeted action of small molecule drugs remains a challenge in medicine