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At the local level, the asthma-related changes include disturbances in the balance of Th1/Th2 pro- and anti-inflammatory cytokines, an increased cellular influx into the bronchi, chronic oxidative stress, and airway hyperreactivity

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SOD is the first line of antioxidant defense and the data shows increased, decreased, or constant activity of this enzyme

[Google Scholar] 165.Mohamed Husien H., Peng W., Su H., Zhou R., Tao Y., Huang J., Liu M., Bo R., Li J

Thoracic Society of Australia and New Zealand (TSANZ) position statement on chronic suppurative lung disease and bronchiectasis in children, adolescents and adults in Australia and New Zealand

It has been reported that at least two DAMPs, namely mutant KRAS protein [172] and the DNA oxidation product 8-hydroxyguanosine/8-OHG [37], are released by ferroptotic cells to mediate macrophage polarization through the activation of AGER/RAGE (advanced glycosylation end-product specific receptor) and STING1/STING/TMEM173 (stimulator of interferon response cGAMP interactor 1) pathways, respectively