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Recently, FDA has accepted a new drug application (not approved) for OCA, a farnesoid X receptor (FXR) agonist, which was shown to improve fibrosis in NASH

By inducing mitochondrial oxidative stress in the RPE through the conditional deletion of the Sod2 gene (which encodes manganese superoxide dismutase, MnSOD), they were able to restore Sod2 expression in the RPE using adeno-associated virus (AAV) vectors

But change takes time

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33 (Suppl): 245254

Its structure allows for consistent evaluation of substrate movement across intracellular compartments, particularly in studies involving energy metabolism at the cellular level