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Very low voiding frequencies or high voided volumes should prompt a diligent search for an alternate diagnosis

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Nicotinamide N-methyltransferase (NNMT) is a cytoplasmic enzyme that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM, the universal methyl donor) to nicotinamide (the NAD + salvage precursor), producing 1-methylnicotinamide and S-adenosyl-L-homocysteine

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More recently, Iwata et al