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Description

This phenomenon is primarily mediated by pathways involving hypoxia-inducible factor 1- (HIF-1)/BCL2-interacting protein (Beclin 1) or PTEN-induced putative kinase 1 (PINK1) and Parkinson protein 2 (Parkin) 19,20,21,22,23

H.ParikhS.FalkM

Barcik, W., Boutin, R

For example, DAMPs such as HMGB1, S100A8/A9, cfDNA, and oxidized low-density lipoprotein (oxLDL) can interact with TLRs, leading to the activation of NF-B and IRF3 pathways through MyD88-dependent or -independent mechanisms

654,655 Perls staining and measurements of non-hemoglobin iron revealed iron overload in the ipsilateral cortex of TBI mice and brain microvascular endothelial cells (BMECs)