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Mar;10(1):e68

This does not mean every patient will experience the same response

The combination of GIP and GLP-1 activation creates a synergistic effect that neither pathway achieves alone, which explains why tirzepatide outperforms semaglutide in head-to-head comparisons

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Since glutamate synaptic transmission is known to involve receptors that reside on dendritic spines, neurons were probed for excitatory synaptic transmission by staining for the glutamatergic presynaptic marker Vesicular Glutamate Transporter 1 (VGLUT1) (Balschun et al