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Chen Z, Zhao P, Luo Z, et al
Pyruvate has been demonstrated to prevent not only diabetic cataracts but also cataracts caused by selenite and ultraviolet radiation 20,21,22,23

The blanket point holds: these compounds are sold for laboratory research only, none is an approved drug, and none has an established human dose

10.1021/jacs.7b02875

Streamlining is the idea underlying IM8

As a result, our review calls upon more attention to personalized approaches in characterization of individual thiamine homeostasis, based on the knowledge of the thiamine-dependent proteins and their tissue-specific features and functions
