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[52] [54] Mesocorticolimbic neurons play a central role in reward and other aspects of motivation

Neuroactive peptides work through mechanisms such as brain-derived neurotrophic factor (BDNF) upregulation, HGF/c-Met signaling, and modulation of monoamine neurotransmitters (Table 4)

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The toxic adverse effects of senolysis may be circumvented by applying a hit and run approach and/or via localized delivery through percutaneous intervention

Glycolytic and tricarboxylic acid cycle metabolites revealed bottlenecks in substrate flow, with build-up of intermediate metabolites consistent with oxidative stress and damage
