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Journal of Clinical Investigation 123(3):966-972

So, for example, 8M urea or 6M guanidine HCl would likely denature GST, preventing the GST-glutathione interaction that serves as the foundation for this purification

In addition to its essential roles in redox homeostasis it functions as cofactors for a multitude of enzymes

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Glutathione is particularly important in detoxification pathways, especially in the liver, where it facilitates the breakdown and removal of metabolic by-products, toxins, and heavy metals