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Microsomal triglyceride transfer protein (MTTP) inhibitors such as mipomersen, if proven safe might also be used to treat these two additional targets (164, 170, 171)

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Vinod Ravi, M.D

In the liver, the uptake of glucose, via the GLUT2 transporter, is solely dependent on glucose levels in the blood and given that the K m of GLUT2 for glucose is high (on the order of 15mM), glucose uptake by the liver only occurs, to a significant degree, during the post-feeding period

A disturbance in the dynamic equilibrium of lipids has been associated with damage to cell structure and increased inflammation and OS leading to neural impairment (274)

Mar 1 2021;282:858-868
