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10.1074/jbc.C300138200 19 ChaoM

Retinoic acid (vitamin A) is an essential supplement in cell culture media for differentiation of various epithelial cell lines (van der Valk et al., 2010)

In the fasted state, amino acids become a major source of energy

Future work should be focused and lean: enroll truly deficient, higher-risk patients, standardize formulations and dosing, and test event-driven hard endpoints aligned to mechanism, while embedding translational markers to confirm on-target biology

doi: 10.1016/0305-0491(85)90195-6

220 An increase in mitochondrial mass and hyperpolarized mitochondria result in mtDNA damage, which affects T cell senescence