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As for targeted therapy in cancer metabolism, gain of function mutations in isocitrate dehydrogenases (IDH1 and IDH2) result in the production of the oncometabolite 2-hydroxyglutarate (140, 141)

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[DOI] [Google Scholar] 141.Voitiuk O., Yegorova A., Scrypynets Y.V., Kashutskyy S., Kluchnik O., Umetskaya I

Considering the favorable properties (e.g., large surface areas, superior bundle strength, and highly electrostatic attraction to neurotransmitters such as DA) of nanotubes, their use merits further research as a new approach for treatment of METH abuse-induced neurotoxicity

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however, choline comprises only about 13% of the weight of phosphatidylcholine (111)