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Acknowledgments We thank the members of Zhens research group for providing feedback and help preparing the manuscript

22 Homozygous ABCB4 cases usually present with more severe phenotypes, such as cirrhosis in pediatric patients

Histone deacetylases (HDACs), as key epigenetic regulators, also possess essential functions in regulating iron metabolism and ferroptosis

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The maximum temperature reached by 100 g/ml of the nanoparticles under this condition was 48.1C

This can be particularly important for people who have difficulty absorbing B vitamins due to certain medical conditions or digestive issues