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Therapeutic implications of cancer epithelial-mesenchymal transition (EMT)

On one hand, the lungs are accessible via inhalation routes, allowing for local delivery of mRNA formulations ( e.g., aerosolized NPs) that can act directly at the diseased site while minimizing systemic exposure [11]

doi: 10.1128/MCB.00118-16

Immunity 13 , 129141 (2000)

Covalent cross-linking of glutathione and carnosine to proteins by 4-oxo-2-nonenal

This effect can be accomplished by making the GABA-A receptors bind more quickly to GABA or by blocking the GABA-B receptors, thus leaving more GABA in the synaptic cleft