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All had BMI of at least 30 kg/m 2 (mean BMI, 38.5 kg/m 2 )

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L.PintanaH.LarssonM.KrizhanovskiiC.NystromT.KleinT.et al
It is a once-weekly investigational triple agonist designed to activate three metabolic receptor pathways at the same time: GLP-1, GIP, and glucagon

In a meta-analysis of 60 studies involving 60,077 T2D patients, GLP-1RAs marginally reduced the UACR in comparison to placebo and other antidiabetic agents, but resulted in no clinically relevant changes in eGFR ( Renoprotective Mechanisms of GLP-1RAs Experimental studies to elucidate the beneficial effects on DKD have been extensively reported