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4i), accompanied by reduced cytosolic NADPH levels (Extended Data Fig

When ERS occurs, the cells are able to maintain intracellular homeostasis through the unfolded protein response

[255] demonstrated that RvD1 reduces joint swelling, leukocyte infiltration, and proinflammatory lipid mediator production while increasing endogenous PRLM levels and accelerating inflammation resolution

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Several Nrf2 activators were currently being tested in human clinical trials

In one study, symptoms of RLS improved with vitamin D supplementation
