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Vitamin B12 plays a role in producing brain chemicals, such as serotonin, that help control mood and other brain functions

Candidate identities, evidence tiers, and source PMIDs are summarized in Supplementary Table S7

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Subjective measurements All participants were asked to self-report their subjective SOL, WASO, TST and a sleep quality rating (SQ, from 1 best sleep ever to 9 worst sleep ever) for the two laboratory nights

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When delta sleep is reduced, as it consistently is in depression, cortisol remains elevated through the night, growth hormone release is blunted, and inflammatory metabolites accumulate in the central nervous system