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CYP11A1 also converts vitamin D3 to the non-calcemic analog 20S-hydroxyvitamin, which significantly reduces the release of pro-inflammatory T cell subsets and pro-inflammatory cytokines, increases the proportion of Treg cells, and improves symptoms in a mouse model of arthritis (68)

*significant P-value: Patients Vs Control

doi: 10.1126/science.284.5418.1365 123

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