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An increased relative risk of death in NSAID users continued during the follow-up period of 4 years

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The agency cited safety risks including potential carcinogenicity, immunogenicity, and concerns about impurities and noted that most of these substances had never undergone rigorous human clinical trials

Vogelmann ES, Reichert JM, Prevedello J, Awe GO, Mataix-Solera J (2013) Can occurrence of soil hydrophobicity promote the increase of aggregates stability