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On the other hand, another study found that 3-month treatment with NR in a PD mouse model resulted in increased NMN and NAD + metabolism marker NAAD but did not increase NAD + levels 287

they are actively transported into specific cellular compartments where they act as essential coenzymesthe biological "keys" that turn on critical enzymatic engines

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Results showed statistically significant reductions in body weight and body fat percentage in the AOD9604 treatment groups compared to placebo, with the highest dose producing average fat mass reductions of approximately 2.6 kg greater than placebo