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6E) in DLD-1 (KRAS G13D/- )

Treatment recommendations are guided by consultation and may evolve over time

Existing literature on ozone therapy reveals research gaps: limited comparative studies between treatments, unclear safety and effectiveness in various musculoskeletal conditions and insufficient understanding of anti-inflammatory effects [3, 18, 31]

Tulpule and Dringen 2013

[DOI] [PubMed] [Google Scholar] 39.Gonzalez-Mariscal L, Betanzos A, Avila-Flores A

This instability, in addition to genetic mutations in one of the mismatch repair genes, can also be the consequence of epigenetic silencing of the MLH1 gene by hypermethylation of its promoter