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It addresses the mechanism that creates the problem

Lyophilization is a sophisticated freeze-drying process where the peptide is frozen and then the surrounding pressure is reduced to allow the frozen water to sublimate directly from a solid to a gas

GCPII catalyzes the hydrolysis of folate, generating monoglutamate, which is then internalized by PCFT within enterocytes

Indeed, albuminuria and reduced kidney function have been addressed as partially responsible for the residual CV risk persisting despite correction of common CV risk factors 79

Another phase I/II study (NCT04330664) is also ongoing to assess MRTX849 in combination with NO155, an SHP2 inhibitor, in patients with the KRAS (G12C) mutation (Table 3)