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Joint Task Force on Allergy-Immunology Practice Parameters (2024): Anaphylaxis: Guidelines From the Joint Task Force on Allergy-Immunology Practice Parameters

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Similarly, oxidation of Met-36 and Met-48 in human stem cell factor (huSCF) derived from Escherichia coli decreased its potency 40% and 60% (respectively) while increasing the dissociation rate constant of SCF dimer by two- to threefold, which suggests an effect on subunit binding and tertiary structure (9)

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This implies that, at physiological pH, these residues will be predominantly found as thiolates, which are much stronger nucleophiles than thiol groups

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