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Genetically predicted higher concentrations of phylloquinone were associated with a lower risk of type 2 diabetes

Ringel T, Frey N, Ringnalda F, et al

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Of particular clinical importance with retatrutide is its glucagon receptor agonism

Garcia-Manero G, Jabbour EJ, Konopleva MY, Daver NG, Borthakur G , DiNardo CD, Bose P, Patel P, Komrokji RS, Shastri A, Roboz GK, Miller RM, Arbe-Barnes S, Reilly M, McGuirk P, Kearney T, Keogh B, Kantarjian HM

These effects are rescued by restoring PPAR expression or activity in vitro and by genetic and pharmacological approaches to lower oxalate overproduction in MASH in vivo