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Further, multicenter trials of new monoclonal antibodies should include appropriate studies to investigate anaphylaxis and to characterize the pathophysiology of these reactions
For example, microbial metabolites such as SCFAs and bile acids can influence hormone secretion by interacting with enteroendocrine cells in the gut (Masse and Lu, 2023)
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however, this effect is greatly diminished by the pH increase caused by PPI treatment (Cunningham et al., 2014)
Flint A, Raben A, Astrup A, Holst JJ
