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Fibrosis is staged F0 (none) through F4 (cirrhosis), and clinical trials typically enroll patients with F2F3 (moderate to advanced) fibrosis because that is where the therapeutic need and the regulatory bar is highest

A., Yamazaki, S., Tei, H., Sakaki, Y

Scale bars = 12 m

The state of endothelial dysfunction is distinguished by a transition toward a pro-inflammatory state to diminished vasodilation and prothrombotic requirements, as well as a reduced ability to endure oxidative stress

M., White S

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