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doi: 10.1016/j.plipres.2022.101207 61 HanZLiuMXieYZengKZhanZChenYet al

The broad substrate scope of NPC2 could explain the more pronounced phenotypes in yeast when NPC2 is deleted, such as sterol accumulation, reduced vacuolar fusion, loss of raft-like domains in the limiting membrane, and, ultimately, vacuolar fragmentation (27, 57, 58)

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