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The role of cell adhesion molecules in the progression of colorectal cancer and the development of liver metastasis

10.1053/j.gastro.2017.05.022 49 WuQ

J.MalatynskaE.CollinsN.FangL.WangJ
Discovery of FXR/PPAR dual partial agonist

In RA compared with healthy tissue, synovial fibroblasts undergo a metabolic shift associated with increased invasive capacity and disease activity

Activation of the somatostatin receptor 3 (SSTR3) leads to its arrestin-dependent ubiquitination and subsequent exit (Shinde et al., 2020) while constitutive ubiquitination of SMO by the ligase WWP1 keeps ciliary SMO levels low under basal conditions (Lv et al., 2021)
