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These reactions introduce or unmask functional groups (e.g., hydroxyl, carboxyl, amino) on the molecule, often resulting in the formation of intermediate metabolites

Peroxynitrite (or its protonated form ONOOH) is a strong oxidizing agent that can lead to depletion of thiol groups, DNA damage, and nitration of proteins

10.1186/s12964-018-0240-3 10.1186/s12964-018-0240-3 [DOI] [PMC free article] [PubMed] [Google Scholar] Li J, Cao F, Hl Y et al (2020a) Ferroptosis: past, present and future

Flow of the study protocol for inclusion and data and sample collection, LEPJAR-NC study, New Caledonia, 20212024

Standard oral capsules often give low bioavailability, especially for direct NAD+ or basic glutathione powders
