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Data availability The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request

By making this substitution at position three, IGF-1 is inhibited from binding to certain proteins in the body, thus increasing the half-life ( Effects of IGF-1 on Growth Hormone Secretion IGF-1 is a peptide that acts similarly to insulin, and its main function in the body is to stimulate growth by increasing GH secretion from the pituitary gland, as well as regulating cell growth and cell death

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It presents with lower urinary tract symptoms, such as dysuria, dyspareunia, increased urinary frequency (often up to 60 times a day) and urinary urgency without urinary tract infection lasting for at least 6 weeks, causing pelvic pain and pressure or discomfort related to bladder filling