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High dose ( 0.5 mg/kg/d) or long-term use may lead to hypoglycemia, especially in patients with diabetes or insulin resistance

NAD+ powers energy production and recovery

121Freyer AM

Reduced ascending aortic strain and distensibility: earliest manifestations of vascular aging in humans

The trade-off is that the 1mg starting dose becomes just 10 units, which can be difficult to measure precisely on a standard syringe

Zhang VX, Sze KMF, Chan LK
