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Given the results of animal trials, this modest benefit of antiVEGF-A/VEGFR therapy against human cancers has been relatively disappointing

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In particular, the harmonization led by the International Council for Harmonisation (ICH) through the E19 guideline , in alignment with foundational principles in ICH E3 clinical study reports , marks a major evolution in how sponsors can optimize safety data collection without compromising regulatory rigor or patient welfare