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The rationale is pharmacologically sound
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doi: 10.1002/mrd.22951

Spontaneous Oxidative Stress and Liver Tumors in Mice Lacking Methionine Adenosyltransferase 1A

Since IGF-1 is used as a drug to treat short stature in GH insensitive children, such as Laron Syndrome patients [31,161,163,180,184192], it is essential to understand how IGF-1 is transported through the vasculature