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Some people also have difficulty absorbing vitamin B12 as a result of bariatric surgery, pernicious anemia, obesity, Imerslund-Grsbeck disease, Addisons disease, or an intrinsic factor deficiency (12)

Best vitamin B12 form for hair and skin For long-term daily use, methylcobalamin is the preferred form

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Although the role of vitamin E (a traditional antioxidant) for kidney diseases is unlikely to help much, 98 , 99 a recent phase IIb randomized controlled trial found that 400 mg tocotrienol-rich vitamin E supplementation for 12 months could ameliorate the progression of diabetic kidney disease (assessed by serum creatinine and eGFR)

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Across a wide range of doses and routes of administration in multiple animal models, no acute lethal or toxic dose has been reported for BPC-157