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The physical properties of phagocytic targets can thus modulate "self" signaling, as they seem to be relevant to the splenic clearance of rigid RBCs after storage or the clearance of rigid pathological cells such as sickle and thalassemic RBCs 160
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A previous report showed cardiac PLN downregulation and short-term improvements in cardiac contractility following hydrodynamic intravenous delivery of a locked nucleic acid (LNA)-modified gapmer ASO targeting PLN in mice with pressure overload induced HF 23
Exposure to fluoride salt blocks meiosis in porcine oocytes, interferes with spindle dynamics, and increases aneuploidy
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