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4 Organoids and their role in basic cancer research 4.1 PDO for modeling tumorigenesis Carcinogenesis is characterized by the accumulation of mutations in specific genes over time, which act as disease drivers (Stratton et al., 2009)

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[47] evaluated the effects of parenteral administration of the alanyl-glutamine dipeptide in total parenteral nutrition associated with liver damage in infant rabbits and observed that this dipeptide supplementation can minimize liver damage and reduce malondialdehyde (MDA) production and hepatocyte apoptosis during total parenteral nutrition