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On the another hand, microglia produced growth factors such as fibroblast growth factor (FGF-2) and insulin-like growth factor I (IGF-1) that are known to be relevant for remyelination

In ex vivo studies, Feng et al
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Gastrointestinal effects dominate: nausea, vomiting, diarrhea, and constipation, usually mild-to-moderate and worst during dose escalation

Data were collected from 20,000 cells for each sample from three independent experiments

Choosing based on which one has more animal evidence is reasonable
