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In animal models, C2 supplementation promoted neuroplasticity, synthesis of neurotrophic factors, modulation of glutamatergic dysfunction, reversal of neuronal atrophy in regions like the hippocampus and amygdala, and improvement in depression-like behavioral symptoms [20, 30, 57, 58]

Front Nutr 9:853058 [DOI] [PMC free article] [PubMed] [Google Scholar] 74.Fgc LN, Carneiro BA, Alves GS, Lins Silva DH, Faria Guimaraes D, Souza LS, Bandeira ID, Beanes G, Miranda Scippa A, Quarantini LC (2022) Metabolomics of major depressive disorder: a systematic review of clinical studies

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That could impact efficacy or necessitate a more frequent delivery schedule, slightly increasing cost

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Advances in Nutrition: An International Review Journal