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In certain illustrative embodiments, , the time period ranges from 30 minutes to 36 hours or longer and all integer values there between

Considering that the ERK1/2 pathway may crosstalk with other signaling pathways, and that reports are found on both ERK 1/2 and the NF-B being involved in cDDP-acquired resistance in BC cells [51, 52], we propose that the constitutive activation of NF-B and of ERK1/2 pathways is modified by exposure of S cells to cDDP, with a slightly increase of NF-B as well as a downregulation of ERK1/2 pathways that might be associated with TNBC survival and its more aggressive characteristics

Koob and Volkow, 2010)

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