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The same authors also showed [59, 70] that the action of both CAT and GPx was insufficient to explain the erythrocyte oxidative catabolism, and proposed [70] a model including Prx2 that, in accordance with their experimental data, could better explain the erythrocyte antioxidant defense system

Cys183 replacement with Ala prevented ERK1 Snitrosylation, restored ERK1/2 phosphorylation, and suppressed GSNO-induced apoptosis

Tabe Y, Jin L, Tanaka N, Andreeff M , Konopleva M

Hepatology 51, 329335 (2010)

An elimination-based strategy is often more useful than universal restriction
