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The NO system is attractive as a research framework because it can connect several observations that otherwise appear separate

This modulation of the immune response not only alleviates symptoms but also promotes long-term healing of the intestinal tissues

That qualitative difference matters

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Both exogenous opioids and endogenous ligands act on peripheral and central terminals of nociceptors to elevate the firing thresholds and activate descending inhibitory pathways that block ascending pain signals