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Prioritize herbs with established PK/PD profiles and avoid combinations with narrow therapeutic index ACDs (e.g., CPT-11, IM) using modelling simulations, HDIs databases, etc

For example, under amino acid deprivation, TORC2 inhibits the Ca 2+ and Cmd1/calmodulin-dependent phosphatase, calcineurin, through the yeast homolog of mammalian SGK-1 (Ypk1), resulting in the activation of Gcn2 and increased autophagy [63, 64]

IV administration allows for the effective delivery of such medications

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Oncotarget 7 , 2776427777 (2016)

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