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Blood 119 , 27092720 (2012)

Deficiencies in key nutrients such as iron, vitamin B12, or thyroid hormones can contribute to poor circulation or anemia, both of which may cause cold hands and feet

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Patients should maintain adequate hydration, especially if experiencing gastrointestinal side effects, to reduce the risk of acute kidney injury

This leads to progressive muscle degeneration, pulmonary dysfunction and cardiomyopathy