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Small molecule drugs targeting ferroptosis have shown promising potential in myocardial I/R injury

SREBP transcription factors, particularly SREBP-2, coordinate mevalonate pathway flux to generate prenylation substrates farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP) through regulated intramembrane proteolysis (198, 201, 202)

doi: 10.1016/j.freeradbiomed.2019.01.016

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The cumulative NAC dose for this regimen reaches 1330 mg/kg over the full treatment duration