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The biological activity of NO is particularly mediated through redox-dependent protein modifications such as S-nitrosation, tyrosine nitration and metal nitrosylation (Besson-Bard et al., 2008

Thus oxidative stress in biological systems is often characterized by the following parameters: 1 ) increase in the formation of radicals and other oxidants, 2 ) decrease in small-molecular-weight and/or lipid-soluble antioxidants, 3 ) disturbance in cellular redox balance, and 4 ) oxidative damage to cellular components (i.e., lipids, proteins, and/or DNA)

10.7860/JCDR/2015/13046.5885 57 KhanI.AgarwalP.ThangjamG

Nielsen OH, Soendergaard C, Vikner ME, Weiss G

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