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Since S is natively an IDP in solution, bearing little to no ordered structure, rational design of compounds to stabilise the monomeric, non-toxic conformation is difficult

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For example, NF-B-activating protein (NKAP) has been discovered to directly bind to m 6 A-methylated SLC7A11 mRNA and then recruit the splicing factor proline and glutamine-rich (SFPQ), which recognize the splice site and thus promotes SLC7A11 mRNA splicing and maturation, ultimately preventing the ferroptosis of glioblastoma cells[163]